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KMID : 0032220100220010102
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Annals of Dermatology
2010 Volume.22 No. 1 p.102 ~ p.105
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A Case of Hydroxychloroquine Induced Acute Generalized Exanthematous Pustulosis Confirmed by Accidental Oral Provocation
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Park Jae-Jeong
Yun Sook-Jung
Lee Jee-Bum
Kim Seong-Jin
Won Young-Ho
Lee Seung-Chul
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Abstract
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Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and this is characterized by acute, nonfollicular sterile pustules on a background of edematous erythema. Hydroxychloroquine (HCQ) has been widely used to treat rheumatic and dermatologic diseases and HCQ has been reported to be an uncommon cause of AGEP. A 38-year-old woman with a 1-year history of dermatomyositis and polyarthralgia was treated with HCQ due to a lack of response to a previous medication. Three weeks after starting HCQ therapy, the pustular skin lesion developed and then this resolved after the HCQ was withdrawn and steroid treatment was started. A similar pustular eruption developed after HCQ was accidentally readministered. (Ann Dermatol 22(1) 102∼105, 2010)
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KEYWORD
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Acute generalized exanthematous pustulosis, Adverse drug reactions, Hydroxychloroquine, Provocation test
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